Dean Ornish from California, America, published his findings in 1998 on the impact of intensive lifestyle changes in reversing coronary heart disease. This randomized controlled trial involved 48 patients who underwent an intervention consisting of a vegetarian diet, exercise, stress management training, smoking cessation, and group psychosocial support for five years. The results showed notable blockage reversal in the intervention group, with greater reversal observed after five years compared to one year. Conversely, the control group experienced blockage progression and a higher incidence of heart attacks during follow-up.